I-nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) umdlavuza umdlavuza ovela ku-nasopharynx, otholakala ngemuva kwekhala lakho nangaphezulu ngemuva komphimbo wakho.
I-Nasopharyngeal carcinoma ayivamile e-United States.Kwenzeka kaningi kwezinye izingxenye zomhlaba - ikakhulukazi i-Southeast Asia.
I-nasopharyngeal carcinoma kunzima ukuyibona kusenesikhathi.Lokhu kungenxa yokuthi i-nasopharynx akulula ukuyihlola futhi izimpawu ze-nasopharyngeal carcinoma zilingisa ezinye, izimo ezivame kakhulu.
I-Nasopharyngeal carcinoma ivame ukuvela kubantu abaneminyaka ephakathi kanye nabantu asebekhulile abangaphezu kweminyaka engama-40 ubudala, futhi inezici ezisobala zesifunda nezomndeni, futhi izinga lezehlakalo e-Guangdong liqala e-China, elaziwa nangokuthi "umdlavuza we-Guangdong".
1.Iziqondiso Zokuxilonga Nokwelashwa Kwe-Nasopharyngeal carcinoma
Ku-2021 Guidelines for the Diagnosis and Treatment of Nasopharyngeal Carcinoma, i-Chinese Society of Clinical Oncology(CSCO) ifake izindlela zokutholwa kwe-serological Ekilasini I ubufakazi bokuxilongwa kwe-nasopharyngeal carcinoma, futhi yaveza ukuthi inhlanganisela ye-EB-VCA-IgA kanye namasosha omzimba e-EB-NA1-IgA EB-virus angakhuphula izinga lokuxilongwa kusenesikhathi kwe-nasopharyngeal carcinoma izikhathi ezi-3 (21%~79%) futhi anciphise ingozi yokufa ngama-88%!I-2019 Expert Consensus on the Clinical Application of Markers for Nasopharyngeal Carcinoma iphinde yaveza ukuthi i-EBV-EA-IgA iwuphawu lokutheleleka kwe-EBV yakamuva noma ukwanda okusebenzayo kwe-EBV, ngezinga eliphezulu lokucaciswa, futhi ivame ukusetshenziselwa ukuhlolwa komdlavuza we-nasopharyngeal. kanye nokuxilongwa kusenesikhathi.
Ucwaningo lukhombisa ukuthi ukutholwa okuthathu okuhlanganisiwe kwe-EBV-VCA-IGA, EBV-EA-IGA kanye ne-EB-NA1-IgA kumboza ngokugcwele i-EBV gene spectrum, okuthuthukisa ngempumelelo ukuzwela nokucaciswa kokutholwa kwe-nasopharyngeal carcinoma, kunciphisa ukutholwa okugejiwe, kuqinisekisa ukuthi ukunemba kokubikezela kwezifo, futhi ubikezela ukuvela kwesifo eminyakeni engu-5-10 kusengaphambili, okulungele ukuhlolwa komdlavuza we-nasopharyngeal ngezinga elikhulu.
2.I-VCA-IgA+EA-IgA+NA1-IgA ekhiqizwe yi-Beijing Beier ingahlinzeka ngephrothokholi yokuxilongwa kusenesikhathi kwe-Nasopharyngeal Carcinoma.
I-Magnetism particulate immuno chemistry luminescence method
| Igama Lomkhiqizo | Isifinyezo |
| Ikhithi yokuthola i-antibody ye-EB VCA-IgA | I-EB-VCA-IgA |
| Ikhithi yokuthola i-antibody ye-EB EA-IgA | I-EB-EA-IgA |
| Ikhithi yokuthola i-antibody ye-EB NA1-IgA | I-EB-NA1-IgA |
Indlela ka-Elisa:
| Igama Lomkhiqizo | Isifinyezo |
| Ikhithi ye-EB virus VCA-IgA Elisa | I-EB-VCA-IgA |
| Ikhithi ye-EB virus EA-IgA Elisa | I-EB-EA-IgA |
| Ikhithi ye-EB virus NA1-IgA Elisa | I-EB-NA1-IgA |
3.Ukusebenza Komkhiqizo
Ikhithi yokuhlola ye-VCA-IgA ekhiqizwe yi-Beijing Beier ingangena esikhundleni sekhithi evamile ye-EU ukuze itholwe kusenesikhathi futhi ihlolwe i-nasopharyngeal carcinoma.
I-British Medical Journal (BMJ) (i-impact factor 16.378) ingelinye lamajenali amane ezokwelapha ahamba phambili emhlabeni.Ngo-2017, ithimba labacwaningi lishicilele iphepha ku-British Medical Journal (BMJ) "Ukuhlolwa kwamakhithi ayisikhombisa e-VCA-IgA ELISA okuxilongwa kwe-nasopharyngeal carcinoma e-China: ukuhlolwa kokulawula icala".
Kuleli phepha, iziguli ze-200 ezine-nasopharyngeal carcinoma (NPC) kanye namasampula e-serum yomuntu angu-200 avamile (SYSUCC) avela e-Sun Yat-sen University Cancer Centre zahlolwa futhi zahlolwa, nokusebenza kwe-EB-VCA-IgA (ELISA) kits ekhiqizwa yi-8. abakhiqizi bemikhiqizo emakethe yasekhaya baqhathaniswa nokuhlolwa kokusebenza.Isiphetho siwukuthi ikhithi ye-EBV-VCA-IgA (ELISA) ekhiqizwe yi-Beijing Beier inomphumela ofanayo wokuxilonga njenge-EBV-VCA-IgA (ELISA) ekhiqizwe i-reagent engenisiwe u-Oumeng, kanye ne-EBV-VCA-IgA (ELISA) Ikhithi ekhiqizwe yi-Beijing Beier ingangena esikhundleni sekhithi engenisiwe ukuze itholwe futhi ihlolwe kusenesikhathi i-nasopharyngeal carcinoma.Ulwazi lwabakhiqizi bomkhiqizo ababambe iqhaza ekuhlolweni luboniswa kuThebula 1, imiphumela yokuhlolwa ikhonjiswe kuThebula 2, futhi iziphetho zokuhlola ziboniswa kuThebula 3.
Isiphetho Sokuhlola
Amakhithi amathathu aphinde ahlanganiswa e-VCA-IgA-BB, HA kanye ne-KSB- abe nemithelela yokuxilonga elingana naleyo yekhithi evamile. Angashintshwa esikhundleni sekhithi evamile futhi izinhlanganisela zawo zingasetshenziswa ekutholweni nasekuhlolweni kusenesikhathi kwe-NPC.
Isikhathi sokuthumela: Feb-23-2023